Pharmacology: Pharmacokinetics: Absorption: Cefalexin is acid stable and is readily absorbed after oral administration, food may delay absorption. Intramuscular doses of the lysine salt are well absorbed up to 15% of a dose is bound to plasma proteins. The half-life had been reported to range from 0.5 to 2.0 hours and this increase with reduced renal function. Cefalexin is widely distributed in the body does not enter cerebrospinal fluid significant quantities. It diffuses across the placenta and small quantities are found in the milk or nursing mothers. About 80% or more of a dose is excreted unchanged in the urine in the first 6 hours by glomerular filtration and tubular secretion. Probenecid delays urinary tract excretion and has been reported to increase biliary excretion.
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