Recent (<1 yr) bleeding, including a history of GI bleeding or genitourinary bleeding of clinical significance; known coagulopathy, platelet disorder or history of thrombocytopenia; platelet count <150,000 cells/mm
3; history of cerebrovascular disease w/in 1 yr; recent epidural procedure; cardiopulmonary resuscitation; chronic hemodialysis; puncture of non-compressible vessel w/in 24 hrs; severe acute or chronic heart failure; cardiogenic shock; mild to moderate liver insufficiency; Hb conc <11 g/dL or hematocrit <34%; concurrent administration of non-thienopyridines P2Y12 inhibitors, adenosine, dipyridamole, sulfinpyrazone & prostacyclin arterial access for femoral sheath placement; severe renal insufficiency (CrCl <30 mL/min). Pregnancy, lactation, childn.
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