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Antigout.
Pharmacology: Pharmacokinetics: Peak plasma concentrations of colchicine are reached within 2 hours of oral use. Colchicine is partially deacetylated in the liver and the unchanged drug and its metabolites are excreted in the bile and undergo intestinal reabsorption. Colchicine is found in high concentrations in leucocytes, kidneys, in liver, and spleen.
Most of the drug is excreted in the urine and this proportion rises in patients with liver disorders. Colchicine is distributed in breast milk.
