Acifre Dosage/Direction for Use

Capsule: Gastroesophageal reflux disease: 20 mg once daily for 4 weeks or as prescribed by the physician.
Dyspepsia: 10 to 20 mg daily for 2 to 4 weeks or as prescribed by the physician.
Peptic ulcer disease: 20 mg daily as single dose, or 40 mg in severe cases or as prescribed by the physician.
NSAID-associated ulceration: 20 mg daily or as prescribed by the physician.
Zollinger-Ellison syndrome: 60 mg once daily or as prescribed by the physician.
Acid aspiration prophylaxis during general anesthesia: 40 mg in the evening before surgery and further 40 mg two to six hours before the procedure or as prescribed by the physician.
Injection: Omeprazole inhibits secretion of gastric acid and is irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase (H⁺/K⁺ATPase), the proton-pump of the gastric parietal cell.
Relief of Acid-Related Dyspepsia: Usual Dose: 10 or 20 mg daily orally for 2-4 weeks.
Gastroesophageal Reflux Disease: Usual Dose: 20 mg orally once daily for 4 weeks, followed by further 4-8 weeks if not fully healed.
Refractory Esophagitis: 40 mg daily may be used. Children weighing 10-20 kg: 10 mg daily orally; >20 kg: 20 mg daily.
Eradication of Helicobacter pylori in Peptic Ulceration: Omeprazole may be combined with antibacterials in dual triple therapy. Effective triple therapy regimens include omeprazole 20 mg twice daily combined with: Amoxicillin 500 mg and metronidazole 400 mg, both 3 times daily; clarithromycin 500 mg and metronidazole 400 mg or (tinidazole 500 mg both twice daily; or with amoxicillin 1 g and clarithromycin 500 mg both twice daily). These regimens are given for 1 week.
Dual therapy regimens eg, omeprazole 40 mg daily with either amoxicillin 750 mg to 1 g twice daily or clarithromycin 500 mg, 3 times daily, are less effective and must be given for 2 weeks. Omeprazole alone may be continued for a further 4-8 weeks.
Administration: Omeprazole may be given orally as the base or magnesium salt, or IV as the sodium salt.