Respira/Respira-D Mechanism of Action

Pharmacology: Respira: Pharmacological classification: Bronchodilator, mucolytic and expectorant.
Respira is a trusted combination of a mucolytic (ambroxol hydrochloride, an expectorant (guaifenesin) and a bronchodilator (salbutamol). All the 3 drugs act in synergy to relieve the patient from productive cough.
Ambroxol is an active N-desmethyl metabolite of the mucolytic bromhexine. Although its mechanism of action has not been fully defined, it may increase the quantity and decrease the viscosity of tracheobronchial secretions. It may also act as an expectorant, increasing mucociliary transport via stimulation of ciliary motility.
Salbutamol acts by stimulating β₂-adrenergic receptors in the lungs to relax bronchial smooth muscle, thereby relieving bronchospasm associated with bronchial asthma, emphysema and chronic bronchitis. Because of this action, salbutamol increases vital capacity, decreases residual volume and reduces airway resistance.
Guaifenesin has expectorant properties.
Respira-D: Pharmacological classification: Antitussive and antiallergic.
Respira-D liquid is a combination of dextromethorphan hydrobromide and chlorpheniramine maleate. Dextromethorphan is an effective antitussive agent for treating uncomplicated, nonproductive cough. Chlorpheniramine is an effective antihistamine for the symptoms related to hay fever, allergic rhinitis, conjunctivitis and seasonal allergic rhinitis.