Hypoglycemic effect of glimepiride is enhanced by anticoagulants, androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, histamine H2 antagonists, magnesium salts, methyldopa, phenylbutazone, probenecid, sulphonamides and urinary acidifiers.
Hypoglycemic effect is inhibited by the following drugs: Blockers, rifampicin, diazoxide, thiazide diuretics and urinary alkalisers.