Not to be applied to the breasts or mucous membranes. Increased risk of thromboembolic disease, breast or uterine cancer & CV incident or cerebral vascular problem. HTN, diabetes, endometriosis, uterine fibroma, hepatic or biliary problems, epilepsy, migraines or severe headaches, renal or cardiac otospongiosis. Prolonged bed rest or planned surgery. Bleeding. Perform medical exam prior to & periodically in the course of treatment. Carry out regular clinical exam of the breasts especially in cases of family history of breast cancer or if patient has cysts or lumps in the breasts. Not to be taken during pregnancy or lactation.