OESTROGEL SHOULD NOT BE USED in the following cases: history or a current venous or arterial thrombo-embolic diseases (phlebitis, pulmonary embolism, angina pectoris, myocardial infarction, cerebral vascular incidents); breast cancer, uterine or any other oestrogen-dependent cancer; endometrial hyperplasia (excessive development of the uterine mucous membrane); undiagnosed vaginal bleeding; certain liver illnesses; known allergies to one of its constituents; porphyria (hereditary disease).