Haemophilia A or B w/ inhibitor or expected to have high anamnestic response Initially 90 mcg/kg IV bolus inj at 2-3 hr intervals to obtain haemostasis, may be increased successively to every 4, 6, 8 or 12 hr if continued therapy is needed.
Mild to moderate bleeding episode (including home therapy) 2-3 inj of 90 mcg/kg at 3-hr intervals, an additional dose of 90 mcg/kg may be administered if required; or as a single inj of 270 mcg/kg. Home therapy: Not to exceed 24 hr.
Serious bleeding episode Initially 90 mcg/kg every 2 hr, can be increased at 3-hr intervals for 1-2 days, then may be increased successively to every 4, 6, 8 or 12 hr. Major bleeding episode may be treated for 2-3 wk.
Invasive procedure/surgery Initially 90 mcg/kg prior to intervention, repeated after 2 hr & then at 2-3 hr intervals for the 1st 24-48 hr. In major surgery, continue dose at 2-4 hr intervals for 6-7 days, may then be increased to 6-8 hr for another 2 wk. Patient undergoing major surgery may be treated for up to 2-3 wk.
Acquired haemophilia Initially 90 mcg/kg IV bolus inj at 2-3 hr intervals, may be increased successively to every 4, 6, 8 or 12 hr once haemostasis is achieved.
Factor VII deficiency 15-30 mcg/kg every 4-6 hr until haemostasis is achieved.
Glanzmann's thrombasthenia At least 3 doses of 90 mcg/kg (range: 80-120 mcg/kg) bolus inj at 2-hr intervals (1.5-2.5 hr).
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