Haemophilia A or B w/ inhibitor or expected to have high anamnestic response
Initially 90 mcg/kg IV bolus inj at 2-3 hr intervals to obtain haemostasis, may be increased successively to every 4, 6, 8 or 12 hr if continued therapy is needed. Mild to moderate bleeding episode (including home therapy)
2-3 inj of 90 mcg/kg at 3-hr intervals, an additional dose of 90 mcg/kg may be administered if required; or as a single inj of 270 mcg/kg. Home therapy: Not to exceed 24 hr. Serious bleeding episode
Initially 90 mcg/kg every 2 hr, can be increased at 3-hr intervals for 1-2 days, then may be increased successively to every 4, 6, 8 or 12 hr. Major bleeding episode may be treated for 2-3 wk. Invasive procedure/surgery
Initially 90 mcg/kg prior to intervention, repeated after 2 hr & then at 2-3 hr intervals for the 1st 24-48 hr. In major surgery, continue dose at 2-4 hr intervals for 6-7 days, may then be increased to 6-8 hr for another 2 wk. Patient undergoing major surgery may be treated for up to 2-3 wk. Acquired haemophilia
Initially 90 mcg/kg IV bolus inj at 2-3 hr intervals, may be increased successively to every 4, 6, 8 or 12 hr once haemostasis is achieved. Factor VII deficiency
15-30 mcg/kg every 4-6 hr until haemostasis is achieved. Glanzmann's thrombasthenia
At least 3 doses of 90 mcg/kg (range: 80-120 mcg/kg) bolus inj at 2-hr intervals (1.5-2.5 hr).