Midazole Mechanism of Action

Antiprotozoal and antibacterial agent.
Pharmacology: Mode of Action: The precise mode of action is unknown, but presumably it is similar to that of metronidazole, because of its selective action against anaerobic organisms. Both metronidazole and tinidazole inhibit DNA synthesis and degrade existing DNA of Clostridium bifermentans. Compared to metronidazole, tinidazole is a more rapid inhibitor of DNA and it has a higher in vitro activity; both of these are probably because tinidazole penetrates the cell more rapidly. Like metronidazole, tinidazole can induce mutations in strains of Salmonella typhimurium.
Pharmacokinetics: Tinidazole is almost completely absorbed following administration by mouth and typically, a peak plasma concentration of about 40 mg/mL is achieved 2 hrs after a single 2-g dose, falling to about 10 mg/mL at 24 hrs and 2.5 mg/mL at 48 hrs. Concentrations >8 mg/mL are maintained by daily maintenance doses of 1 g. The plasma elimination half-life of tinidazole is 12-14 hrs. About 12% of Midazole is protein bound and majority is eliminated through the urine.