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Blood glucose level should be monitored more often during concomitant therapy with sulfonylurea and stabilization of diabetic patients with metformin and insulin should be carried out because of the possibility of hypoglycemia.
Annual monitoring of folic acid and vitamin B12 level are recommended during long-term metformin therapy because Metforex may decrease their absorption.
Regular monitoring of renal function is advised in all diabetic patients because metformin is excreted by the kidney.
Caution is recommended when concomitantly used with other drugs eg, alcohol, cimetidine and furosemide.
Metforex is not recommended for use during pregnancy and in nursing women and in children.
