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Pharmacotherapeutic group: Enzymes, other drugs for disorders of the musculo-skeletal system. ATC code: M09AB.
Pharmacology: Pharmacodynamics: Serratiopeptidase acts as a fibrinolytic, anti-inflammatory, anti-oedematous and inactivates bradykinin. It is able to increase the diffusion of antibiotics and cytostatic agents in tissue.
Pharmacokinetics: There is still no data available on the bioavailability in humans. Animal experimental findings shows that Serratiopeptidase is absorbed from the duodenum. After 10 mg/kg Serratiopeptidase administered intraduodenally to dogs, radioimmunoassay identified peak concentrations in the lymph (26 ng/ml), in the portal vein blood (16 ng/ml) and in arterial blood (about 11 ng/ml), by binding to alpha2-macroglobulin Serratiopeptidase loses its antigenicity; while maintaining a sufficient proteolytic activity.
