Invokana

Invokana Special Precautions

canagliflozin

Manufacturer:

Janssen-Cilag

Distributor:

DKSH
Full Prescribing Info
Special Precautions
This medicine is subject to additional monitoring. This will allow quick identification of new safety information. The patient can help by reporting any side effects he/she may get. See Side Effects for how to report side effects.
This medicine has been prescribed for the patient only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as the patient's.
Talk to the doctor, pharmacist or nurse before taking this medicine, and during treatment: about what the patient can do to prevent dehydration; if the patient has type 1 diabetes (the body does not produce any insulin). Invokana should not be used to treat this condition; if the patient experiences rapid weight loss, feeling sick or being sick, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to the breath, a sweet or metallic taste in the mouth or a different odour to the urine or sweat, contact a doctor of the nearest hospital straight away. These symptoms could be a sign of "diabetic ketoacidosis" - a rare but serious, sometimes life-threatening problem the patient can get with diabetes because of increased levels of "ketone bodies" in the urine or blood, seen in tests. The risk of developing diabetic ketoacidosis may be increased with prolonged fasting, excessive alcohol consumption, dehydration, sudden reductions in insulin dose, or a higher need of insulin due to major surgery or serious illness; if the patient has diabetic ketoacidosis (a complication of diabetes with high blood sugar, rapid weight loss, nausea, or vomiting). Invokana should not be used to treat this condition; if the patient has severe kidney problems or is on dialysis; if the patient has severe liver problems; if the patient has ever had serious heart disease or if he/she has had a stroke; if the patient is on medicines to lower the blood pressure (anti-hypertensives) or has ever had low blood pressure (hypotension). More information is given as follows in Interactions; It is important to check the feet regularly and adhere to any other advice regarding foot care and adequate hydration given by the health care professional. The patient should notify the doctor immediately if he/she notices any wounds or discolouration, or if he/she experiences any tenderness or pain in the feet. Some studies indicate that taking canagliflozin may have contributed to the risk of lower limb amputation (mainly toe amputations).
If any of the previously mentioned apply to the patient (or the patient is not sure), talk to the doctor, pharmacist, or nurse before taking this medicine.
Kidney function: The kidneys will be tested by a blood test before the patient starts taking and while on this medicine.
Urine glucose: Because of how this medicine works, the urine will test positive for sugar (glucose) while the patient is on this medicine.
Invokana contains lactose: If the patient has been told by the doctor that he/she has an intolerance to some sugars, contact the doctor before taking this medicine.
Driving and using machines: Invokana has no or negligible influence on the ability to drive, cycle, and use tools or machines. However, dizziness or lightheadedness has been reported, which may affect the ability to drive, cycle, or use tools or machines.
Taking Invokana with other medicines for diabetes called sulphonylurea (such as glimepiride or glipizide) or insulin can increase the risk of having low blood sugar (hypoglycaemia). Signs include blurred vision, tingling lips, trembling, sweating, pale looking, a change in mood, or feeling anxious or confused. This may affect the ability to drive, cycle, and use any tools or machines. Tell the doctor as soon as possible if the patient gets any of the signs of low blood sugar.
Use in Children: Children and adolescents: Invokana is not recommended for children and adolescents under 18 years.
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