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Pregnancy: Studies in animals have shown reproductive toxicity. There have been reports of multiple congenital abnormalities (including brachycephalia, ears dysplasia, giant anterior fontanelle, femoral bowing and radio-humeral synostosis) in infants whose mothers were treated for at least three or more months with high doses (400-800 mg daily) of fluconazole for coccidioidomycosis. So use of Flusum is not advised during pregnancy.
Breast-feeding: Fluconazole passes into breast milk to reach concentrations lower than those in plasma. Use of Flusum during lactation is not advised.
Fertility: Fluconazole did not affect the fertility of male or female rats.
