The concomitant use of salbutamol sulfate and other oral sympathomimetic agents is not recommended since such combined use may lead to deleterious cardiovascular effects. Salbutamol sulfate should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants because the action of salbutamol sulfate on the vascular system may be potentiated. Beta-receptor-blocking agents and salbutamol sulfate inhibit the effect of each other. Caution is advised in the co-administration of β-agonists with non-potassium-sparing diuretics, it may result in hypokalemia.