Delamanid is an antibiotic. It is used together with other medicines to treat a lung infection known as tuberculosis (TB).
Take Delamanid exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take Delamanid together with food or immediately after a meal. Try to take it at the same time each day.
Take this medicine at regular intervals. Complete the entire course of medicine. If you don't, the infection will not be properly controlled.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances. If you often forget to take your medicine, let your doctor and pharmacist know.
If you miss a dose, do not take the missed dose in between meals. Take only at your next scheduled dose and meal. DO NOT double a dose to make up for a missed dose.
Alert your doctor if you have very low albumin level in the blood, as Delamanid may not be suitable for you.
Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Delamanid.
Do not take Delamanid with carbamazepine (medicine for fits or seizures).
Inform your doctor if you have the following conditions:
- low levels of potassium, magnesium or calcium in the blood
- heart disease e.g. abnormal heart rhythm, history of heart attack
- liver disease
- kidney disease
- HIV infection
Let your doctor know if you are pregnant or breastfeeding.
What must I do to prevent spreading TB to other people?
TB is spread through the air, especially when you cough, sneeze or laugh.
You may still be able to infect others while undergoing treatment for TB. If your doctor has told you to stay at home so that you do not spread TB to other people, follow his instructions. You may need to sleep in a bedroom separate from your family members.
Always cover your mouth when you cough, sneeze or laugh.
If you use tissue paper, seal it in a plastic bag before you throw it away.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Routine tests for liver and kidney function, and an eye examination may be needed while you are being treated with this medicine.
- Sputum culture and chest X-ray also needs to be done.
Delamanid may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: nausea, vomiting, difficulty of sleeping, headache, anxiety, tremor, numbness or tingling sensation in the hands and feet, diarrhoea, palpitations, ringing in the ears, loss of appetite and abdominal pain.
If you develop rashes, breathlessness, swollen mouth or eyes, stop the medicine and inform your doctor quickly. These could be signs of an allergic reaction.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Delamanid if you are taking carbamazepine (medicine for fits or seizures).
Inform your doctor and pharmacist if you are taking any of these medicines:
- medicines for HIV infection e.g. ritonavir, lopinavir
- medicines to treat fungal infection e.g. itraconazole
- medicines for abnormal heart rhythmhigh blood pressure or heart disease e.g. amiodarone, disopyramide, procainamide, quinidine, sotalol
- certain antibiotics e.g. moxifloxacin, erythromycin
- medicine for mood disorders e.g. phenothiazines, haloperidol
- medicine for allergy e.g. terfenadine
- medicines for nausea and vomiting e.g. droperidol, domperidone
- medicine for stomach disorder e.g. cisapride, diphemanil
- cholesterol-lowering medicines e.g. probucol
- strong painkillers e.g. methadone
- medicine for cancer e.g. vinca alkaloids
- medicine for certain types of leukaemia e.g. arsenic trioxide
This list does not include all medicines that may interact with Delamanid.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Avoid alcohol.
Store in a cool, dry place away from the reach of children. Keep tablets in their original package to protect from light.
Medicines must not be used past the expiry date.
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