Cetil Mechanism of Action

Pharmacology: Mode of Action: Cetil, like other cephalosporins, is bactericidal. It acts by inhibiting the enzymatic reactions necessary for the production of a stable bacterial cell wall.
Pharmacokinetics: Cefuroxime axetil is hydrolysed to free cefuroxime after oral administration. Cefuroxime is subsequently distributed throughout the extracellular fluids. The volume of distribution after a 1-g dose is 11.1-13.7 L/1.73 m². Therapeutic concentrations are achieved in the cerebrospinal fluid (CSF) only in inflamed conditions. Peak serum concentrations of 7-10 mg/L has been reported with cefuroxime axetil when consumed along with food, while 40-50 mg/L serum concentration has been reported following IV bolus injection of cefuroxime. IM dose of cefuroxime sodium 750 mg resulted in peak plasma concentration of about 27 mcg/mL. Approximately 50% of serum cefuroxime is bound to protein. Cefuroxime sodium is primarily eliminated by the kidneys, with urinary recovery about 35% and an elimination half-life of 1.5 hrs.
Cefuroxime is rapidly excreted in high concentration through the kidney with over 90% of the given dose recovered in the urine within 6 hrs of injection. No unhydrolysed ester is detected in serum. Small amounts of cefuroxime are excreted in the bile.
Microbiology: Antibacterial Activity: Cefuroxime has bactericidal activity against a wide range of common pathogens including many β-lactamase-producing strains. Cefuroxime is stable to many bacterial β-lactamases, especially plasmid-mediated enzymes that are commonly found in enterobacteriaceae. Cefuroxime has been demonstrated to be active against most strains of the following microorganisms both in vitro and in clinical infections.
Aerobic Gram-Positive Microorganisms: Staphylococcus aureus (including β-lactamase-producing strains), Streptococcus pneumoniae, Streptococcus pyogenes.
Aerobic Gram-Negative Microorganisms: Escherichia coli, Haemophilus influenzae (including β-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including β-lactamase-producing strains), Neisseria gonorrhoeae (including β-lactamase-producing strains).