Prior to administration, susceptibility to cefixime should be tested to prevent manifestation of resistant bacteria, and the duration of therapy should be the minimum needed for the treatment.
A patient should be asked about his/her condition in order to predict the reaction eg, shock and also previous skin reaction should be tested.
Cefix should be administered to patients with hypersensitivity to cephem antibiotic only when the treatment is justified.
Patients who are hypersensitive to penicillin antibiotics; who have allergic reactions to cefixime eg, bronchiectasis, eruption, hives; with severe renal disorder; who cannot ingest orally or parenterally; who are elderly and patients with poor systemic condition.
Use in pregnancy & lactation: Since safety in pregnancy has not been established, cefixime should be used in pregnancy only when the expected benefits clearly outweigh the potential risks.
It is not known whether cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with Cefix.
Use in children: Safe use in neonates and prematures has not been established.
Use in the elderly: Because physiological function decreases with age, adverse effects may manifest easily. Hemorrhage may occur due to deficiency in vitamin K.