Shock: Shock may rarely occur so careful observation should be considered. If malaise, intraoral abnormal sense, stridor, dizziness, feeling of defecation, tinnitus, diaphoresis occur, administration should be discontinued and/or appropriate therapy should be instituted.
Anaphylactic: Anaphylactoid symptoms may occur so careful observation should be considered.
Hypersensitivity: Skin rashes, urticaria, drug fever and pruritus. Erythema multiforme, Stevens-Johnson syndrome and serum sickness-like reactions have been reported.
Hematologic: Occasionally, eosinophilia and thrombocythemia may occur. Rarely, hemolytic anemia, thrombocytopenia and prothrombin disorder may occur.
Hepatic: Occasionally, elevations of GOT, GPT, AL-P may occur.
Renal: Rare cases of severe renal disorder including acute kidney failure have been reported; therefore, tests should be performed regularly. If any symptom occurs, administration should be discontinued and/or appropriate therapy should be instituted.
Gastrointestinal: Rarely, severe colitis accompanied by hemafecia of pseudomembranous colitis may occur. If aneilemia, frequent diarrhea occur, appropriate therapy should be instituted eg, discontinuance of administration. Occasionally, nausea, vomiting, loose stool, diarrhea, or rarely, aneilemia, anorexia may also occur.
Superinfection: Rarely, stomatitis and candidiasis may occur.
Avitaminosis: Rarely, avitaminosis K (eg, hypoprothrombinemia, bleeding tendency) and avitaminosis B group (eg, glossitis, stomatitis, anorexia, neuritis) may occur.
Skin: Rarely, Lyell's syndrome and Stevens-Johnson syndrome may occur. In this case, administration should be discontinued and/or appropriate therapy should be instituted.
Respiratory: Interstitial pneumonia accompanied by flush, cough, dyspnea, disorder of chest x-ray, eosinophilia and PIE syndrome may occur rarely. If these symptoms occur, administration should be discontinued and/or appropriate therapy including administration of adrenocortical hormone should be instituted.
Others: Occasionally, ache and dizziness may occur.