Bilaxten Drug Interactions

Please inform the doctor or pharmacist if the patient is taking or has recently taken any other medicines, including medicines obtained without a prescription.
Interaction with food: Food significantly reduces the oral bioavailability of bilastine by 30%.
Interaction with grapefruit juice: Concomitant intake of bilastine 20 mg and grapefruit juice decreases bilastine's bioavailability by 30%. This effect may also apply to other fruit juices. The degree of bioavailability decrease may vary between manufacturers and fruits. The mechanism responsible for this interaction is an inhibition of OATP1A2, an uptake transporter for which bilastine is a substrate. Medicinal products that are substrates or inhibitors of OATP1A2, such as ritonavir or rifampicin, may likewise have the potential to decrease plasma concentrations of bilastine.
Interaction with ketoconazole or erythromycin: Concomitant intake of bilastine 20 mg and ketoconazole or erythromycin increases bilastine AUC 2-fold and C_max 2-3-fold. These changes can be explained by interaction with intestinal efflux transporters, since bilastine is a substrate for P-glycoprotein and is not metabolised. These changes do not appear to affect the safety profile of bilastine and ketoconazole or erythromycin, respectively. Other medicinal products that are substrates or inhibitors of P-glycoprotein, such as cyclosporine, may likewise have the potential to increase plasma concentrations of bilastine.
Interaction with diltiazem: Concomitant intake of bilastine 20 mg and diltiazem 60 mg increases the C_max of bilastine by 50%. This effect can be explained by interaction with intestinal efflux transporters and does not appear to affect the safety profile of bilastine.
Interaction with alcohol: The psychomotor performance after concomitant intake of alcohol and 20 mg of bilastine is similar to that observed after intake of alcohol and placebo.
Interaction with lorazepam: Concomitant intake of bilastine 20 mg and lorazepam 3 mg for 8 days does not potentiate the depressant Central Nervous System effects of lorazepam.