Azithromycin should be used with caution in patients with impaired hepatic function. No adjustment in dose is required in patients with mild renal impairment (creatinine clearance 40 ml/min), but there is no data regarding the use of Azithromycin in patients with more severe renal function impairment. Azithromycin is rated FDA pregnancy category B. It is not known whether Azithromycin is distributed into human breast milk or not, therefore caution should be exercised when Azithromycin is administered to nursing mother.