Ascozin Drug Interactions

Ascorbic acid increases salicylates (increases a risk of crystalluria), ethinylestradiol, benzylpenicillin and tetracyclines concentrations in blood, and decreases concentration of oral contraceptives in blood. It reduces anticoagulation effect of coumarin derivatives. It improves iron absorption in intestine. It increases general clearance of ethyl alcohol. Quinolone drugs, calcium chloride, salicylate, corticosteroid decrease vitamin C reserve when used for a long term. Corticosteroids (cortisone and prednisolone), which are administered in chronic diseases (arthritis, bronchial asthma etc.), also reduce vitamin C and zinc levels.
Concurrent usage of ascorbic acid and deferoxamine enhances tissue toxicity of iron, especially in cardiac muscle that can cause decompensation of circulatory system. It can be used only in 2 hours after deferoxamine injection. A long-term use of high doses in patients, who are treated by disulfiram, inhibits disulfiram-alcohol reaction.
High doses of Ascorbic acid decreases efficacy of tricyclic depressants.