Increased blood conc of salicylates, ethinylestradiol, benzylpenicillin & tetracyclines. Decreased blood conc of OCs. Reduced anticoagulation effect of coumarin derivatives. Improved Fe absorption. Increased clearance of ethyl alcohol. Decreased reserve w/ quinolones, CaCl2
, salicylate, corticosteroid. Reduced levels w/ corticosteroids (cortisone & prednisolone). Enhanced tissue toxicity of Fe w/ deferoxamine inj. High doses of vit C inhibited disulfiram-alcohol reaction. Decreased efficacy of TCAs.