Allopac Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Indications/Uses Dosage/Direction for Use Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Allopurinol

Indications/Uses

Management of primary or secondary gout; elevated serum & urinary uric acid levels in patients receiving cancer therapy.

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Dosage/Direction for Use

Adult Mild gout 200-300 mg/day. Moderately severe tophaceous gout 400-600 mg/day. May be administered in divided doses (for 7,300 mg) or as single dose. Max: 800 mg/day. Acute gouty attacks Initially 100 mg then 100 mg once wkly until serum uric acid levels ≤6 mg/dL.

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Administration

Should be taken with food.

Contraindications

Hypersensitivity. Mild uratemia w/out symptoms (uric acid <90 mg/L). Lactation. Childn (except malignancies esp leukemia, & Lesch-Nyhan syndrome).

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Allopac detailed prescribing information

Special Precautions

Treatment should not be started until acute attack of gout has stopped. Hepatic impairment, renal failure. Hematopoiesis disorders. Patients on treatment for HTN or cardiac insufficiency. Maintain sufficient fluid intake. Monitor liver function tests as well as serum urate conc & urinary urate/uric acid levels. May impair ability to drive or operate machinery. Pregnancy. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Diarrhea, nausea; increased alkaline phosphatase & SGOT/SGPT. Acute attacks of gout. Rash, maculopapular rash.

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Drug Interactions

Prolonged activity w/ 6-mercaptopurine or azathioprine. Prolonged hypoglycaemic activity w/ chlorpropamide. Increased effect of anticoagulants. Enhanced bone marrow suppression w/ cyclophosphamide & other cytotoxic agents. Enhanced toxicity of ciclosporin. Increased levels of theophylline due to inhibition of metabolism. Increased plasma t_½ of vidarabine. Frequent skin rash w/ ampicillin or amoxicillin. Decreased therapeutic activity of allopurinol w/ uricosuric agents eg probenecid. Enhanced action of salicylates. Fe supplements, phenytoin, ampicillin, amoxicillin.

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Storage

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MIMS Class

Hyperuricemia & Gout Preparations

ATC Classification

M04AA01 - allopurinol ; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.

Regulatory Classification

POM

Presentation/Packing

Form

Allopac tab 100 mg

Packing/Price

10 × 10's

Allopac

allopurinol

Manufacturer:

Pacific Pharma

Distributor:

AA Medical