Tab/susp Adult Herpes simplex 200 mg 5 times daily at 4-hrly intervals (omit nighttime dose) for 5 days, may be doubled to 400 mg in severely immunocompromised patient or those w/ impaired gut absorption.
Suppression of herpes simplex in immunocompetent patient 200 mg qds at approx 6-hrly intervals or 400 mg bd at approx 12-hrly intervals, may titrate dose to 200 mg bd or tds.
Prophylaxis of herpes simplex infection in immunocompromised patient 200 mg qds at approx 6-hrly interval.
Treatment & prophylaxis of herpes simplex infections in immunocompromised childn >2 yr Adult dose,
<2 yr ½ adult dose.
Renal impairment CrCl <10 mL/min 200 mg bd at approx 12-hrly intervals.
Varicella & herpes zoster 800 mg 5 times daily at approx 4-hrly interval for 7 days.
Childn ≥6 yr 800 mg qds for 5 days,
2 to <6 yr 400 mg qds for 5 days,
<2 yr 200 mg qds for 5 days.
Severe renal impairment CrCl <10 mL/min 800 mg bd at approx 12-hrly intervals.
Moderate renal impairment CrCl 10-25 mL/min 800 mg tds at approx 8-hrly intervals.
Inj Herpes simplex & varicella zoster Adult 5 mg/kg IV infusion every 8 hr.
Infant & childn ≥3 mth 250 mg/m
2 IV infusion every 8 hr.
Herpes encephalitis, immunocompromised patient w/ varicella zoster infection Adult 10 mg/kg IV infusion every 8 hr.
Infant & childn 500 mg/m
2 IV infusion every 8 hr.
Prophylaxis of herpes simplex in immunocompromised patient Adult dose.
Known suspected neonatal herpes 20 mg/kg IV every 8 hr for 21 days (for disseminated & CNS disease) or 14 days (for disease limited to skin & mucous membranes).
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