Zosaar Use In Pregnancy & Lactation

Pregnancy: When used in pregnancy during the second and third trimesters, medicines that act directly on the renin-angiotensin system can cause injury and even death in the developing fetus. When pregnancy is detected, Zosaar 50mg Tablet should be discontinued as soon as possible.
Although there is no experience with the use of Zosaar 50mg Tablet in pregnant women, animal studies with losartan potassium have demonstrated foetal and neonatal injury and death, the mechanism of which is believed to be pharmacologically mediated through effects on the renin-angiotensin system. In humans, foetal renal perfusion, which is dependent upon the development of the renin angiotensin system, begins in the second trimester; thus, risk to the foetus increases if Zosaar 50mg Tablet is administered during the second or third trimesters of pregnancy.
Nursing Mothers: It is not known whether losartan is excreted in human milk. Because many medicines are excreted in human milk and because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.