HTN; risk reduction of CV morbidity & mortality in hypertensive patients w/ left ventricular hypertrophy; renal protection in type 2 diabetic patients w/ proteinuria.
HTN & renal protection in type 2 diabetic patient w/ proteinuria 50 mg once daily, may be increased up to 100 mg once daily. Risk reduction of CV morbidity & mortality in hypertensive patient w/ left ventricular hypertrophy 50 mg once daily, may be increased up to 100 mg daily &/or combination w/ low-dose hydrochlorothiazide.
Reduced levels of active metabolite by rifampin, fluconazole. Increased serum K w/ K-sparing diuretics, K supplements or K-containing salt substitutes. Attenuated antihypertensive effect w/ indomethacin.
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