HTN & renal protection in type 2 diabetic patient w/ proteinuria 50 mg once daily, may be increased up to 100 mg once daily. Risk reduction of CV morbidity & mortality in hypertensive patient w/ left ventricular hypertrophy 50 mg once daily, may be increased up to 100 mg daily &/or combination w/ low-dose hydrochlorothiazide.
Reduced levels of active metabolite by rifampin, fluconazole. Increased serum K w/ K-sparing diuretics, K supplements or K-containing salt substitutes. Attenuated antihypertensive effect w/ indomethacin.