Zolon Overdosage

Overdosage is usually manifested by varying degrees of central nervous system depression ranging from drowsiness to coma according to the quantity ingested. In mild cases, symptoms include drowsiness, confusion and lethargy;  in more serious cases, symptoms may include ataxia, hypotonia, hypotension, respiratory depression and coma. Other risk factors, such as combining zopiclone with other CNS depressants (including alcohol), the presence of concomitant illness and the debilitated state of the patient, may contribute to the severity of the symptoms and very rarely can result in fatal outcome.
Symptomatic and supportive treatment in an adequate clinical environment is recommended. Attention should be paid to respiratory and cardiovascular functions.
Gastric lavage is only useful when performed soon after ingestion.
Haemodialysis is of no value due to the large volume of distribution of zopiclone.
Flumazenil may be a useful antidote.