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Pregnancy: No clinical data on exposed pregnancies are available for celecoxib. The potential for human risk in pregnancy is unknown, but cannot be excluded. Celecoxib, as with other drugs inhibiting prostaglandin synthesis, may cause uterine inertia and premature closure of the ductus arteriosus during the last trimester. Celecoxib is contraindicated in pregnancy and in women who can become pregnant (see Contraindications and Precautions). If a woman becomes pregnant during treatment, celecoxib should be discontinued.
Breastfeeding: Celecoxib is excreted in the milk of lactating rats at concentrations similar to those in plasma.
Administration of celecoxib to a limited number of lactating women has shown a very low transfer of celecoxib into breast milk. Women who take celecoxib should not breastfeed.
