Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. Serious skin infections eg, exfoliative dermatitis, SJS & TEN. Not a substitute for ASA in prophylaxis of CV thromboembolic diseases. Risk of GI complication w/ NSAIDs; history of GI disease eg, ulceration, GI bleeding; CV events eg, HTN, hyperlipidemia, DM, smoking; history of cardiac failure, left ventricular dysfunction, pre-existing oedema; hypovolaemia; peripheral arterial disease. May mask fever & other signs of inflammation. Patients who are known or suspected to be CYP2C9 poor metabolizers. Ensure adequate hydration. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Closely monitor BP during therapy. Avoid use w/ non-aspirin NSAID. Concomitant use w/ other NSAID or ASA; diuretics; ACE inhibitors, AIIA; warfarin, other anticoagulants. Moderate to severe hepatic & severe renal impairment. Not to be used during pregnancy & lactation. Not to be used in childn. Elderly.