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Intentional overdosing of ceftaroline fosamil is unlikely. Limited data in patients receiving higher than recommended ceftaroline fosamil dosages show similar adverse reactions as observed in the patients receiving recommended dosages. Treatment under such circumstances should follow local standard medical practice.
Patients with renal impairment: Relative overdosing could occur in patients with moderate to severe renal impairment. Neurological sequelae, including encephalopathy, have been noted in cases where beta-lactam antibiotics (including cephalosporins) have been given to patients with impaired renal function without reducing the dose (see Dosage & Administration).
Ceftaroline can be removed by haemodialysis; over a 4 hour dialysis session, approximately 74% of a given dose was recovered in the dialysate.
