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Moderate intoxication: Tinnitus, hearing disorders, headache and vertigo are reported in all cases of overdosage.
Severe intoxication: Fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular shock, respiratory failure, severe hypoglycaemia.
Treatment: The moderate intoxication can be can be eliminated by reducing the dose. Meanwhile for the severe intoxication need to be treated at hospital. Gastric lavage and administration of activated carbon, monitoring of the acid-base balance. Alkaline diuresis to attain a urine pH of between 7.5 and 8; increased alkaline diuresis must be considered if the plasma Salicylate concentration exceeds 500mg/l (3.6 mmol/l) in adults or 300 mg/l (2.2 mmol/l) in children. Optionally haemodialysis in cases of severe intoxication. Fluid loss must be compensated and Symptomatic treatment.
