Vocinti Dosage/Direction for Use

Adults: Gastric ulcer: The usual dose is 20 mg of vonoprazan once a day. Administration should be limited to 8 weeks.
Duodenal ulcer: The usual dose is 20 mg of vonoprazan once a day. Administration should be limited to 6 weeks.
Reflux esophagitis (erosive esophagitis): The usual dose is 20 mg of vonoprazan once a day. Administration should be limited to 4 weeks. However, when the effect is insufficient, treatment may be continued for up to 8 weeks. In addition, for the maintenance of healing of reflux esophagitis in patients with repeat recurrence and relapse of the condition, a dose of 10 mg is administered once a day; however, when the efficacy is inadequate, a dose of 20 mg may be administered once a day. The duration of administration in the long-term efficacy clinical Study OCT-001 is up to 52 weeks.
Prevention of recurrence of gastric ulcer or duodenal ulcer during NSAIDs administration: The usual dose is 10 mg of vonoprazan once a day.
Adjunct to Helicobacter pylori eradication: Usually, the following 3 drugs are orally administered at the same time twice daily for 7 days: 20 mg vonoprazan, 750 mg amoxicillin, and 200 mg clarithromycin. The dose of clarithromycin may be appropriately increased as required, however, the upper limit is 400 mg twice daily. When Helicobacter pylori eradication treatment with 3 drugs consisting of a proton pump inhibitor, amoxicillin, and clarithromycin fails, alternative treatment with the following 3 drugs is recommended; 20 mg vonoprazan, 750 mg amoxicillin, and 250 mg metronidazole, orally administered at the same time twice daily for 7 days. The doses of antibiotic should follow the respective label recommendations for H. pylori eradication.
Method of Administration: Vonoprazan can be taken without regard to food or timing of food.