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Thiamine reportedly may enhance the effects of neuromuscular blocking agents.
Pyridoxine Hydrochloride reverses the therapeutic effects of levodopa by stimulating the decarboxylation of dopa to dopamine. Concomitantly administration of decarboxylase inhibitor, carbidopa, with levodopa can prevent the reversal by pyridoxine of levodopa's effects.
Pyridoxine Hydrochloride should not be administered in dosage more than 5 mg daily to patients receiving levodopa alone.
Absorption of Cyanocobalamin from GI tract may be decreased by aminoglycosides antibiotics, colchicine, anticonvulsants (e.g. phenytoin, phenobarbital, primidone), cobalt irradiation of small bowel and be excessive alcohol intake lasting longer than 2 weeks.
Chloramphenicol reportedly may antagonize the hematopoietic response to vitamin B12 in vitamin B12 deficiency patients.
