Hypersensitivity to the active substance or to any of the excipients listed in Description.
Hepatic impairment (i.e. cirrhosis or active liver disease) or transaminases exceeding 3 X upper limit of normal (see Dosage & Administration and Precautions).
Concomitant use of potent CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin) (see Interactions).