Urosin Drug Interactions

The effects of salbutamol and isoprenaline on the bronchi are not impaired by atenolol. Atenolol can therefore be used in patients with obstructive airway diseases provided appropriate care is taken.
Where ventricular function is impaired, β-blockers and calcium antagonists of the verapamil type should be combined with care. Such combinations must be avoided in conduction disorders.
Care is needed when β-blockers are combined with class I antiarrhythmic agents, eg disopyramide. Care is also required when a change is made from clonidine to atenolol. If clonidine is given together with a β-blocker and treatment is discontinued, the β-blocker should be discontinued a few days before the gradual withdrawal of clonidine.
It is not advisable to discontinue a β-blocker before anaesthesia. Certain reactions during anaesthesia are altered by β-blockade. The anaesthetist must therefore be informed if a patient being treated with atenolol has to have a general anaesthetic. Vagal stimulation can be counteracted by atropine 1-2 mg IV.
In some circumstances, atenolol can potentiate the hypoglycaemic effects of insulin.