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Effects on Fertility: Selexipag had no effect on fertility of male and female rats. In the rat pre- and post-natal development study, selexipag induced no effects on maternal and pup reproductive function.
Use in pregnancy (Category B1): Use in Pregnancy should be avoided. Pregnant women were excluded from the trial and there is no data in human pregnancy. Selexipag was not teratogenic in rats and rabbits.
Use in Lactation: It is unknown whether selexipag or its metabolites are excreted in human milk.
In rats, selexipag and/or its metabolites are excreted in the milk. Breastfeeding is not recommended during treatment with UPTRAVI.
