Fluid and electrolyte disturbance, congestive heart failure, hypokalaemic alkalosis, hypertension. Muscle weakness, steroid myopathy, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones, tendon rupture. Peptic ulcer, perforation of the small and large bowel, pancreatitis, abdominal distention, ulcerative oesophagitis. Impaired wound healing, thin fragile skin, ecchymoses, erythema, increased sweating, allergic dermatitis, urticaria, angioneurotic oedema. Convulsions, increased intracranial pressure with papilloedema, vertigo, headache. Menstrual irregularities, development of cushingoid state. Suppression of growth in children. Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, in trauma, surgery or illness. Decreased carbohydrate tolerance. Manifestations of diabetes mellitus. Increased requirement for insulin or oral hypoglycemic agent in diabetic patients. Hirsutism, posterior subcapsular cataract. Increased intraocular pressure. Glaucoma, exophthalmos, hypersensitivity, thromboembolism, weight gain, increase appetite, nausea, malaise.
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