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Pharmacology: Pharmacodynamics: Triamcinolone is a synthetic glucocorticoid and has potent anti-inflammatory, hormonal and metabolic effects. It is essentially devoid of mineral corticoid activity when administered in therapeutic doses.
a) Promote gluconeogenesis, increase the deposition of glucogen in the liver and inhibit the utilization of glucose.
b) Increase the breakdown of protein. The amino-acid produced are available to support the accelerated glyconeogenesis.
c) Increase the mobilization of fat and stimulate its synthesis and storage.
d) Increase the glomerular filtration rate. The urinary excretion is unaffected.
e) Increase calcium excretion.
f) Depress the production of eosinophils and lymphocytes but stimulate erythropoiesis and the production of polymorphonuclear leucocytes. They inhibit antibody formation and depress the response of tissue to inflammation.
Pharmacokinetics: Triamcinolone is readily and almost completely absorbed after oral administration. About 40% is bound to plasma protein. Its half-life in plasma is about 2 to 5 hours. The metabolic reaction involved consist of 6b-hydroxylation. It is excreted renally, mainly as inactive metabolite.
