Thelban Tablet: Each tablet contains: Albendazole 200 mg.
Thelban Suspension: Each 5 mL contains: Albendazole 100 mg, Methylparaben (as preservative) 0.15%, Propylparaben (as preservative) 0.02%.
Pharmacology: Pharmacodynamics: THELBAN (Albendazole) is an anthelmintic exhibits vermicidal, ovicidal and larvacidal activity.
Pharmacokinetics: Albendazole is poorly absorbed from gastro-intestinal tract after oral administration, but rapidly undergoes extensive first-pass metabolism. The principal metabolite (albendazole sulfoxide) has anthelmintic activity, and a plasma half-life of about 8 ½ hours, it is excreted in the urine together with other metabolites including albendazole sulfone and the 2-amino-sulfoxide and 2-amino sulfone.
Anthelmintic which exhibits vermicidal, ovicidal and larvacidal activity in the treatment of Roundworm (Ascaris lumbricoides), Whipworm (Trichuris trichiura), Pinworm or Threadworm (Enterobius vermicularis), Hookworm (Ancylostoma duodenale and Necator americanus), Strongyloides stercoralis, Taenia solium, Taenia saginata and Opisthorchis viverrini.
Adults and children over 2 years of age: The usual dosage is 400 mg as a single dose with meal.
In cases of Strongyloides infestation: The usual dosage is 400 mg once daily for three consecutive days.
In cases of Opisthorchis viverrini: The usual dosage is 400 mg twice daily for three consecutive days.
Route of Administration: Oral.
No symptoms of overdosage have been reported. Should they occur, symptomatic treatment should be provided.
Albendazole should not be administered during pregnancy or in women thought to be pregnant.
Patients receiving high doses of albendazole such as those with hydatid disease, should be supervised closely.
Pregnancy: Albendazole should not be administered during pregnancy or in women thought to be pregnant.
Lactation: It is not known whether it is excreted in human milk, caution should be exercised when albendazole is administered.
Since albendazole is poorly absorbed from the gastro-intestinal tract at the usual therapeutic doses, side effects have generally been restricted to gastro-intestinal disturbances such as transient abdominal pain and diarrhoea.
However, adverse effects have been reported more frequently with high doses tried in the treatment of hydatid disease and have included allergic reactions, raised liver enzymes values, leucopenia and alopecia.
Dexamethasone: Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in 8 neurocysticercosis patients.
Theophylline: Albendazole induces cytochrome P450 1A in human hepatoma cells. Therefore, it is recommended that plasma concentrations of theophylline be monitored during and after treatment with albendazole.
Store at temperature not exceeding 30°C.
P02CA03 - albendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.
Thelban powd for oral susp 100 mg/5 mL
20 mL x 1's
Thelban powd for oral susp 200 mg/5 mL
10 mL x 1's
Thelban tab 200 mg
50 × 2's
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