Synflorix Drug Interactions

Synflorix can be given concomitantly with any of the following monovalent or combination vaccines [including DTPa-HBV-IPV/Hib and DTPw-HBV/Hib]: diphtheria-tetanus-acellular pertussis vaccine (DTPa), hepatitis B vaccine (HBV), inactivated polio vaccine (IPV), Haemophilus influenzae type b vaccine (Hib), diphtheria-tetanus-whole cell pertussis vaccine (DTPw), measles-mumps-rubella vaccine (MMR), varicella vaccine, meningococcal serogroup C conjugate vaccine (CRM₁₉₇ and TT conjugates), meningococcal serogroups A, C, W-135 and Y conjugate vaccine (MenACWY-TT), oral polio vaccine (OPV) and rotavirus vaccine. Different injectable vaccines should always be given at different injection sites.
Clinical studies demonstrated that the immune responses and the safety profiles of the co-administered vaccines were unaffected, with the exception of the inactivated poliovirus type 2 response (seroprotection ranging from 78% to 100% across studies) and MenACWY-TT vaccine when co-administered with a booster dose of Synflorix following a 3 doses primary series (lower antibody geometric mean concentration (GMC) and opsonophagocytic assay geometric mean titre (OPA GMT) for pneumococcal serotype 18C only). Enhancement of antibody response to Hib-TT conjugate, diphtheria and tetanus antigens was observed. The clinical relevance of the previously mentioned observations is unknown.
As with other vaccines, it may be expected that in patients receiving immunosuppressive treatment an adequate response may not be elicited.