Sun-Dianox Overdosage

Initial signs of overdosage may include dryness of the skin and mucous membranes, mydriasis, restlessness, flushing, hyperthermia, and tachycardia followed by lethargy or coma, hypotonic reflexes, nystagmus, pinpoint pupils, and respiratory depression. Respiratory depression may be evidenced as late as 30 hours after ingestion and may recur despite of an initial response to narcotic antagonist. Treat all possible Sun-Dianox overdosages as serious and maintain medical observation for at least 48 hours, preferably under continuous hospital care.
Treatment: In the event of overdose, induction of vomiting, gastric lavage, establishment of a patent airway, and possibly mechanically assisted respiration are advised. In noncomatose patients, a slurry of 100g of activated charcoal can be administered immediately after the induction of vomiting or gastric lavage. A pure narcotic antagonist (eg. naloxone) should be used in the treatment of respiratory depression caused by Sun-Dianox.