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Specific drug interaction studies have not been conducted with SIMPONI.
Concurrent use of SIMPONI with other biological therapeutics: The combination of SIMPONI with other biological therapeutics used to treat the same conditions as SIMPONI, including anakinra and abatacept, is not recommended (see Precautions).
Live vaccines/therapeutic infectious agents: Live vaccines should not be given concurrently with SIMPONI (see Precautions).
Therapeutic infectious agents should not be given concurrently with SIMPONI (see Precautions).
Methotrexate: No significant effect of methotrexate on the clearance of SIMPONI administered intravenously was observed. Following subcutaneous administration, concomitant use of methotrexate resulted in higher steady-state trough concentrations of SIMPONI in patients with RA, PsA, or AS. However, the data do not suggest the need for dose adjustment of either SIMPONI or methotrexate (see Pharmacology: Pharmacokinetics under Actions).
