Shinallerg Drug Interactions

MAOIs: Sympathomimetic agents may cause a hypertensive crisis if used during treatment with MAOIs. Concomitant use with MAOIs is therefore contraindicated.
Sedating anti-histamines: Sedating anti-histamines can enhance the sedating effects of CNS depressants including alcohol, hypnotics, opioid analgesics, anxiolytic sedatives and anti-psychotics. They also have an additive anti-muscarinic action with other anti-muscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). As systemic absorption of antazoline is possible, caution should be exercised when using this product concomitantly with these medicinal products.
Bromocriptine: Possible systemic exposure of tetryzoline can lead to its interaction with bromocriptine and may result in hypertension, severe headache, seizures and psychosis.
Interactions resulting in hypertension: A theoretical possibility of severe hypertension cannot be excluded when Antazoline/Tetryzoline is used with drugs such as digitalis, beta-adrenergic blockers, guanetidine, reserpine, methyldopa or anti-hypertensive agents (particularly those whose action involves the sympathetic nervous system).
Interactions resulting in arrhythmia: The pharmacodynamic properties of Antazoline/Tetryzoline suggest its interaction with cyclopropane and halogenated anesthetic agents such as chloroform, halothane, enflurane or isoflurane may provoke or worsen ventricular arrhythmias.