Not to be administered by IV push or bolus inj. Interrupt therapy if serious infusion-related or hypersensitivity reaction occurs. Not to be initiated in patients w/ any clinically significant active infection eg, active TB. Severe active CNS lupus or severe active lupus nephritis; chronic infection, history of recurrent infections or known risk factors for infection; history of primary immunodeficiency; known risk factors for development or reoccurrence of malignancy. Consider anti-TB therapy prior to initiation in patients w/ untreated latent TB. Not recommended in combination w/ biologic therapies. Avoid concurrent use w/ live or attenuated vaccines. Severe renal impairment or ESRD. Women of childbearing potential should use effective contraception. Not recommended during pregnancy. Lactation. Childn & adolescents <18 yr. Elderly ≥65 yr.