Incompatibilities: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.
Special precautions for disposal and other handling: Saphnelo is supplied as a single-dose vial. The solution for infusion should be prepared and administered by a healthcare professional, using aseptic technique as follows: Preparation of solution: 1. Visually inspect the vial for particulate matter and discolouration. Saphnelo is a clear to opalescent, colourless to slightly yellow solution. Discard the vial if the solution is cloudy, discoloured or visible particles are observed. Do not shake the vial.
2. Dilute 2.0 mL of Saphnelo solution for infusion in an infusion bag to 100 mL with sodium chloride 9 mg/mL (0.9%) solution for injection.
3. Mix the solution by gentle inversion. Do not shake.
4. Any concentrate remaining in the vial must be discarded.
5. It is recommended that the solution for infusion should be administered immediately after preparation. If the solution for infusion has been stored in a refrigerator (see Shelf life under Storage), allow it to reach room temperature (15°C - 25°C) prior to administration.
Disposal: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.