There is no specific antidote for metronidazole overdosage. Therefore, management of the patient should consist of symptomatic and supportive therapy. Due to the minimal systemic blood levels of metronidazole afforded by topical application of the gel, systemic drug overdosage is unlikely. Furthermore, acute oral toxicity studies in rats have shown no toxic action with doses of up to 5g of the gel per kilogram body weight which represents the highest dose used.
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