No drug-drug or drug-disease interactions were observed in any subjects of the population. The well documented disulfiram-like effect of metronidazole with alcohol consumption was not reported in any of the patients treated with topical metronidazole. This is noteworthy since patients were not restricted from alcohol consumption. Drug-drug and drug-disease interactions are expected to be minimised with the use of topical metronidazole since this low dose affords only minimal serum concentrations but should be kept in mind when Metronidazole topical gel is prescribed for patients who are receiving anticoagulant treatments. Oral metronidazole has also been reported to potentiate the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. However, the effect of topical metronidazole on prothrombin is not known.
Sign Out
