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In the event of overdosage and prolonged neuromuscular block, the patient should continue to receive ventilator support and sedation. Upon start of spontaneous recovery an acetylcholinesterase inhibitor (e.g. neostigmine, edrophonium, pyridostigmine) should be administered in adequate doses. When administration of an acetycholinesterase inhibiting agent fails to reverse the neuromuscular effects of Rocuronium Bromide Injection, ventilation must be continued until spontaneous breathing is restored. Repeated dosage of an acetycholinesterase inhibitor can be dangerous.
In animal studies, severe depression of cardiovascular function, eventually leading to cardiac collapse did not occur until a cumulative dose of 750 x ED 90 (135 mg rocuronium bromide per kg body weight) was administered.
